Hello,

More of my philosophy about Metformin and about Statin and
about I3C (Indole-3-carbinol)..

I am a white arab from Morocco, and i think i am smart since i have also
invented many scalable algorithms and algorithms..

I will say that Metformin causes a deficiency of vitamin B-12 in 10% of patients, so you can take concurrently supplementation of multivitamins that protects against this, and you need a daily dose of 2.4 mcg of vitamin B-12 for adults, but multivitamins for adults contains around 45 mcg, so it will solve the problem efficiently, and yu have to know that
Metformin can "inhibit"(that means prevent) DNA damage, and it slows aging and prevent age-related disease and increase lifespan by 15% for patients of the type 2 diabetes, so i think it solves the following problem of genetic mutations that hurts that happen in the human's DNA humans to die in average at age 84 years, read the following new news so that to understand:

Mystery of why humans die around 80 may finally be solved

Read more here:

https://www.yahoo.com/news/mystery-why-humans-die-around-173539273.html?guccounter=1&guce_referrer=aHR0cHM6Ly9sLmZhY2Vib29rLmNvbS8&guce_referrer_sig=AQAAAIH45fhQCx7vRzqAI8BT_K8DcBgLvcM0EiDs8iojqKsEwy453BBl3EIy3SAawL6LqfBVZXp-YDpbangcU9-A_wxUgWdXgBY-_7VDM8FtE0KeaUCpV6sowwyg3IfIeUHjXxbveHPJwGUwi_B4Vz9C5pOXM8ZPS0BBoBB2-eN5bQhe

And more about Metformin and Statin and cancers..

Metformin found not to prevent prostate cancer:

Read more here:

https://www.renalandurologynews.com/home/news/urology/prostate-cancer/metformin-found-not-to-prevent-prostate-cancer/

https://www.sciencedaily.com/releases/2020/03/200312114150.htm

But Metformin, Statin Combination Reduces Mortality in High-Risk
Prostate Cancer

Read more here to notice:

"Patients who received the combination also experienced a reduction in
risk for all-cause mortality (32%) and prostate cancer mortality (54%).
However, metformin alone did not have any significant effects on
all-cause and prostate cancer mortality.

https://www.curetoday.com/view/metformin-statin-combination-reduces-mortality-in-highrisk-prostate-cancer

And notice that the longer half-lives of rosuvastatin, atorvastatin,
pitavastatin, and pravastatin allow these agents to maintain a
therapeutic drug concentration over a 24-hour period and allow alternate
administration times.

And taking Metformin prevents other cancers, read here to notice it:

"Indeed, observational studies with time-related biases have reported
extraordinary effects of ranging from 20 to 94% reductions in the risk
of cancer (10), suggesting that metformin may be more effective at
preventing or treating cancer than preventing the cardiovascular
complications of diabetes."

https://care.diabetesjournals.org/content/37/7/1786#:~:text=Indeed%2C%20observational%20studies%20with%20time,the%20cardiovascular%20complications%20of%20diabetes.

And read the following interesting news about Statin:

Statins starve cancer cells to death

https://www.sciencedaily.com/releases/2020/03/200312114150.htm

And more precision about I3C (Indole-3-carbinol) and cancer..

I have just read the following article, i invite you to read it:

Broccoli and Brussels sprouts: Cancer foes

https://news.harvard.edu/gazette/story/2019/05/beth-israel-researchers-uncover-anti-cancer-drug-mechanism-in-broccoli/

But i think that the above article is not speaking about the following
research that says the following about I3C (Indole-3-carbinol):

"In vivo studies showed that I3C inhibits the development of different
cancers in several animals when given before or in parallel to a
carcinogen. However, when I3C was given to the animals after the
carcinogen, I3C promoted carcinogenesis. This concern regarding the
long-term effects of I3C treatment on cancer risk in humans resulted in
some caution in the use of I3C as a dietary supplement in cancer
management protocols"

Read more here to notice it:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989150/

So i don't advice to take I3C(Indole-3-carbinol) as a dietary
supplement, because I3C(Indole-3-carbinol) can reduce the risk of cancer
, but still you can have cancer even if you take I3C(Indole-3-carbinol)
, so it is dangerous to take I3C(Indole-3-carbinol) because taking
I3C(Indole-3-carbinol) after the carcinogen promotes carcinogenesis(read
my writing above to notice it).

Thank you,
Amine Moulay Ramdane.